Ontology highlight
ABSTRACT:
SUBMITTER: Merkenschlager J
PROVIDER: S-EPMC6567521 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Blood 20190130 10
Best known for presenting antigenic peptides to CD4<sup>+</sup> T cells, major histocompatibility complex class II (MHC II) also transmits or may modify intracellular signals. Here, we show that MHC II cell-autonomously regulates the balance between self-renewal and differentiation in B-cell precursors, as well as in malignant B cells. Initiation of MHC II expression early during bone marrow B-cell development limited the occupancy of cycling compartments by promoting differentiation, thus regul ...[more]