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Triazole functionalized acyclic cucurbit[n]uril-type receptors: host·guest recognition properties.

ABSTRACT: We report the synthesis of three new triazole functionalized acyclic CB[n]-type receptors (2-4) by click chemistry. The compounds have good solubility in water (?8 mM) and do not undergo strong self-association (Ks ? 903 M-1). We measured the binding constants of 2-4 toward guests 9-24 and compared the results to those obtained for the prototypical acyclic CB[n]-type receptor 1. The X-ray crystal structure of 4 is also described.

SUBMITTER: Xue W

PROVIDER: S-EPMC6572757 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Triazole functionalized acyclic cucurbit[n]uril-type receptors: host·guest recognition properties.

Xue Weijian W Zavalij Peter Y PY Isaacs Lyle L

Organic & biomolecular chemistry 20190601 22

We report the synthesis of three new triazole functionalized acyclic CB[n]-type receptors (2-4) by click chemistry. The compounds have good solubility in water (≥8 mM) and do not undergo strong self-association (Ks ≤ 903 M-1). We measured the binding constants of 2-4 toward guests 9-24 and compared the results to those obtained for the prototypical acyclic CB[n]-type receptor 1. The X-ray crystal structure of 4 is also described. ...[more]

PMID: 31112196

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