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Acyclic Cucurbit[n]uril Dendrimers.

ABSTRACT: The synthesis of acyclic cucurbit[n]uril dendrimers G1-G3 that bear four dendrons on their aromatic sidewalls via thiolate S(N)2 chemistry is reported. G1-G3 are polycationic and can bind to pEGFP plasmid DNA as shown by dynamic light scattering (DLS), gel electrophoresis, and scanning electron microscopy (SEM). The gene delivery ability of G1-G3 is presented.

SUBMITTER: Sigwalt D

PROVIDER: S-EPMC4670575 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Acyclic Cucurbit[n]uril Dendrimers.

Sigwalt David D Ahlbrand Sarah S Zhang Mingming M Vinciguerra Brittany B Briken Volker V Isaacs Lyle L

Organic letters 20151123 23

The synthesis of acyclic cucurbit[n]uril dendrimers G1-G3 that bear four dendrons on their aromatic sidewalls via thiolate S(N)2 chemistry is reported. G1-G3 are polycationic and can bind to pEGFP plasmid DNA as shown by dynamic light scattering (DLS), gel electrophoresis, and scanning electron microscopy (SEM). The gene delivery ability of G1-G3 is presented. ...[more]

PMID: 26593638

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