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Acyclic Cucurbit[n]uril-Type Receptors: Optimization of Electrostatic Interactions for Dicationic Guests.

ABSTRACT: The synthesis of acyclic CB[n]-type host (1) is reported. By optimizing the placement of the sulfate groups nearby the electrostatically negative ureidyl C═O portals, the binding affinity of this class of receptors toward hydrophobic (di)ammonium guest molecules (5-23) is maximized. The X-ray crystal structures of 1·6a and 1·6d are reported.

SUBMITTER: Lu X

PROVIDER: S-EPMC7576436 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Acyclic Cucurbit[n]uril-Type Receptors: Optimization of Electrostatic Interactions for Dicationic Guests.

Lu Xiaoyong X Zebaze Ndendjio Sandra A SA Zavalij Peter Y PY Isaacs Lyle L

Organic letters 20200610 12

The synthesis of acyclic CB[n]-type host (1) is reported. By optimizing the placement of the sulfate groups nearby the electrostatically negative ureidyl C═O portals, the binding affinity of this class of receptors toward hydrophobic (di)ammonium guest molecules (5-23) is maximized. The X-ray crystal structures of 1·6a and 1·6d are reported. ...[more]

PMID: 32520574

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Triazole functionalized acyclic cucurbit[n]uril-type receptors: host·guest recognition properties.

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