Ontology highlight
ABSTRACT:
SUBMITTER: Siriyong T
PROVIDER: S-EPMC6591303 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Siriyong Thanyaluck T Murray Rachael M RM Bidgood Lucy E LE Young Simon A SA Wright Florence F Parcell Benjamin J BJ Voravuthikunchai Supayang Piyawan SP Coote Peter J PJ
Scientific reports 20190624 1
The aim of the study was to determine the efficacy of dual β-lactam combination treatments derived from eight approved drugs against Galleria mellonella larvae infected with MDR strains of P. aeruginosa. Carbapenem-resistant P. aeruginosa NCTC 13437 and an unrelated clinical isolate were used to infect G. mellonella larvae and the efficacy of twenty-eight dual β-lactam combination therapies were compared to their constituent monotherapies. For the most potent combinations identified, penicillin- ...[more]