Dataset Information

Diagnostic and prognostic values of serum activin-a levels in patients with acute respiratory distress syndrome.

ABSTRACT:

Background

We aimed to evaluate whether serum activin-A levels are elevated and have any value in predicting severity and prognosis in acute respiratory distress syndrome (ARDS).

Methods

Retrospective cohort study was performed with patients who were admitted to MICU with diagnosis of ARDS and have serum samples stored within 48?h of Intensive care unit (ICU) admission between March 2013 and December 2016 at a single tertiary referral hospital. Serum activin-A levels were measured with ELISA kit, and were compared with those of normal healthy control and non-ARDS sepsis patients.

Results

Total 97 ARDS patients were included for the study. Levels of Activin-A were elevated in ARDS patients compared to those of healthy controls (Log-transformed activin-A levels 2.89?±?0.36 vs. 2.34?±?0.11, p?ConclusionsSerum activin-A levels in ARDS patients are elevated. However, its levels are weakly associated with ARDS outcomes.

SUBMITTER: Kim JM

PROVIDER: S-EPMC6593589 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Publications

Diagnostic and prognostic values of serum activin-a levels in patients with acute respiratory distress syndrome.

Kim Jee-Min JM Lee Jung-Kyu JK Choi Sun Mi SM Lee Jinwoo J Park Young Sik YS Lee Chang-Hoon CH Yim Jae-Joon JJ Yoo Chul-Gyu CG Kim Young Whan YW Han Sung Koo SK Lee Sang-Min SM

BMC pulmonary medicine 20190625 1

<h4>Background</h4>We aimed to evaluate whether serum activin-A levels are elevated and have any value in predicting severity and prognosis in acute respiratory distress syndrome (ARDS).<h4>Methods</h4>Retrospective cohort study was performed with patients who were admitted to MICU with diagnosis of ARDS and have serum samples stored within 48 h of Intensive care unit (ICU) admission between March 2013 and December 2016 at a single tertiary referral hospital. Serum activin-A levels were measured ...[more]

PMID: 31238942

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Project description:ObjectivesSoluble suppression of tumorigenicity-2 is a biomarker of myocardial strain and inflammation. The characteristics of acute respiratory distress syndrome include inflammation and cardiovascular dysfunction. We sought to determine whether plasma soluble suppression of tumorigenicity-2 concentration is associated with outcome and response to conservative fluid management and whether soluble suppression of tumorigenicity-2 concentration discriminates acute respiratory distress syndrome from decompensated heart failure.DesignA retrospective analysis of the Fluid and Catheter Treatment Trial, a multi-center randomized controlled trial of conservative fluid management in the acute respiratory distress syndrome, as well as of a cohort of patients with decompensated heart failure.SettingTwenty acute care hospitals.PatientsEight hundred twenty-six patients with acute respiratory distress syndrome and 209 patients with acutely decompensated heart failure.Measurements and main resultsNonsurvivors had higher day 0 (p < 0.0001) and day 3 (p < 0.0001) soluble suppression of tumorigenicity-2 concentrations. After adjustment for severity of illness, higher soluble suppression of tumorigenicity-2 concentration was associated with mortality, with odds ratioadj 1.47 (95% CI, 0.99-2.20; p = 0.06) at day 0, 2.94 (95% CI, 2.00-4.33; p < 0.0001) at day 3, and 3.63 (95% CI, 2.38-5.53; p < 0.0001) if soluble suppression of tumorigenicity-2 increased between days. Cumulative fluid balance was more positive among patients with higher day 0 (median, 5,212 mL [interquartile range, 200-12,284 mL] vs median, 2,020 mL [interquartile range, -2,034 to 7,091 mL]; p < 0.0001) and day 3 soluble suppression of tumorigenicity-2 (median, 7,678 mL [interquartile range, 2,217-14,278 mL] vs median, 1,492 mL [interquartile range, -2,384 to 6,239 mL]; p < 0.0001). Soluble suppression of tumorigenicity-2 showed excellent discriminative ability between the Fluid and Catheter Treatment Trial and heart failure populations (area under receiver-operating characteristic curve = 0.98; p < 0.0001).ConclusionsHigher soluble suppression of tumorigenicity-2 concentrations are associated with worse outcome in acute respiratory distress syndrome and may have value for discriminating acute respiratory distress syndrome from heart failure.

Dataset Information

Diagnostic and prognostic values of serum activin-a levels in patients with acute respiratory distress syndrome.

Background

Methods

Results

Publications

Diagnostic and prognostic values of serum activin-a levels in patients with acute respiratory distress syndrome.

Similar Datasets

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