Simple mechanics of protein machines.
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ABSTRACT:
SUBMITTER: Flechsig H
PROVIDER: S-EPMC6597773 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Publications
Simple mechanics of protein machines.
Flechsig Holger H Mikhailov Alexander S AS
Journal of the Royal Society, Interface 20190619 155
While belonging to the nanoscale, protein machines are so complex that tracing even a small fraction of their cycle requires weeks of calculations on supercomputers. Surprisingly, many aspects of their operation can be however already reproduced by using very simple mechanical models of elastic networks. The analysis suggests that, similar to other self-organized complex systems, functional collective dynamics in such proteins is effectively reduced to a low-dimensional attractive manifold. ...[more]
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