Increases in Colonic Bacterial Diversity after ω-3 Fatty Acid Supplementation Predict Decreased Colonic Prostaglandin E2 Concentrations in Healthy Adults.

ABSTRACT:

Background

The intestinal microbiome is an important determinant of inflammatory balance in the colon that may affect response to dietary agents.

Objective

This is a secondary analysis of a clinical trial, the Fish Oil Study, to determine whether interindividual differences in colonic bacteria are associated with variability in the reduction of colonic prostaglandin E2 (PGE2) concentrations after personalized supplementation with ω-3 (n-3) fatty acids.

Methods

Forty-seven healthy adults (17 men, 30 women, ages 26-75 y) provided biopsy samples of colonic mucosa and luminal stool brushings before and after personalized ω-3 fatty acid supplementation that was based on blood fatty acid responses. Samples were analyzed using 16S ribosomal RNA sequencing. The data analyses

SUBMITTER: Djuric Z 

PROVIDER: S-EPMC6602899 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature