Ontology highlight
ABSTRACT:
SUBMITTER: Lee MR
PROVIDER: S-EPMC6616849 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Lee Meng-Rui MR Huang Hung-Ling HL Lin Shu-Wen SW Cheng Meng-Hsuan MH Lin Ya-Ting YT Chang So-Yi SY Yan Bo-Shiun BS Kuo Ching-Hua CH Lu Po-Liang PL Wang Jann-Yuan JY Chong Inn-Wen IW
Journal of clinical medicine 20190606 6
Weekly rifapentine and isoniazid therapy (known as 3HP) for latent tuberculosis infection (LTBI) is increasingly used, but systemic drug reactions (SDR) remain a major concern. Methods: We prospectively recruited two LTBI cohorts who received the 3HP regimen. In the single-nucleotide polymorphism (SNP) cohort, we collected clinical information of SDRs and examined the <i>NAT2</i>, <i>CYP2E1</i>, and <i>AADAC</i> SNPs. In the pharmacokinetic (PK) cohort, we measured plasma drug and metabolite lev ...[more]