Unknown

Dataset Information

0

Three-Component Cascade Reaction of 1,1-Enediamines, N,N-Dimethylformamide Dimethyl Acetal, and 1,3-Dicarbonyl Compounds: Selective Synthesis of Diverse 2-Aminopyridine Derivatives.

ABSTRACT: A novel approach has been developed for the synthesis of three kinds of highly functionalized 2-aminopyridine derivatives (APDs) through a three-component reaction of 1,1-enediamines (EDAMs) 1, N,N-dimethylformamide dimethyl acetal (DMF-DMA) 2, and 1,3-dicarbonyl compounds 3-5 via a base-promoted cascade reaction, producing the desired products in good to excellent yields. This method represents a route to obtain a novel class of APDs in a concise, rapid, and practical manner. This approach is particularly attractive because of the following features: low cost, mild temperature, atom economy, high yields, and potential biological activity of the product.

SUBMITTER: Zi QX 

PROVIDER: S-EPMC6648487 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Three-Component Cascade Reaction of 1,1-Enediamines, <i>N</i>,<i>N</i>-Dimethylformamide Dimethyl Acetal, and 1,3-Dicarbonyl Compounds: Selective Synthesis of Diverse 2-Aminopyridine Derivatives.

Zi Quan-Xing QX   Yan Sheng-Jiao SJ   Yang Chang-Long CL   Li Kun K   Lin Jun J  

ACS omega 20190207 2

A novel approach has been developed for the synthesis of three kinds of highly functionalized 2-aminopyridine derivatives (APDs) through a three-component reaction of 1,1-enediamines (EDAMs) <b>1</b>, <i>N</i>,<i>N</i>-dimethylformamide dimethyl acetal (DMF-DMA) <b>2</b>, and 1,3-dicarbonyl compounds <b>3</b>-<b>5</b> via a base-promoted cascade reaction, producing the desired products in good to excellent yields. This method represents a route to obtain a novel class of APDs in a concise, rapid  ...[more]

Similar Datasets

Unknown (1R,3S)-1,1'-(1,3-Dihydro-2-benzofuran-1,3-diyl)bis(1,3-dimethyl-urea).
| S-EPMC2967959 | biostudies-literature
Unknown 1,1'-Dimethyl-4,4'-(propane-1,3-di-yl)dipyridinium tetra-bromidocadmate(II).
| S-EPMC2959373 | biostudies-literature
Unknown Dimethyl 2,2'-[2,2'-bi(1H-1,3-benzimidazole)-1,1'-di-yl]diacetate.
| S-EPMC3414963 | biostudies-literature
Unknown 2,2'-[(E,E)-1,1'-(2,2-Dimethyl-propane-1,3-diyldinitrilo)diethyl-idyne]diphenol.
| S-EPMC2969254 | biostudies-literature
Unknown 3,3'-Dimethyl-1,1'-[(1,3-dihy-droxy-propane-2,2-di-yl)dimethyl-idene]diimidazolium bis-(hexa-fluoro-phosphate).
| S-EPMC3011425 | biostudies-literature
Unknown 3,3'-Dimethyl-1,1'-(propane-1,3-di-yl)diimidazol-1-ium bis(hexafluoro-phosphate).
| S-EPMC2960103 | biostudies-literature
Unknown 2,2'-Dimethyl-1,1'-[2,2-bis-(bromo-methyl)propane-1,3-di-yl]dibenzimidazole hemihydrate.
| S-EPMC3297910 | biostudies-literature
Unknown Translation of Diverse Aramid- and 1,3-Dicarbonyl-peptides by Wild Type Ribosomes <i>in Vitro</i>.
| S-EPMC6661870 | biostudies-literature
Unknown 3,3-Dimethyl-1,1-(propane-1,3-di-yl)diimidazol-1-ium tetra-bromido-cadmate(II).
| S-EPMC3008047 | biostudies-literature
Transcriptomics Exposure of zebrafish embryos to organic solvents, dimethylformamide and dimethyl sulfoxide
2011-10-06 | GSE32593 | GEO