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Role of Green Chemistry in Antipsychotics' Electrochemical Investigations Using a Nontoxic Modified Sensor in McIlvaine Buffer Solution.

ABSTRACT: A new low-cost green electrochemical sensor based on nontoxic polyethylene glycol (PEG) and silver nanoparticles was used to improve the sensitivity of the carbon paste electrode for the investigation of olanzapine (OLZ) in dosage arrangements and in the existence of its coadministered drug fluoxetine and in the drug formulation. Scanning electron microscopy measurements were carried out to emphasize the morphology of the electrode surface. Cyclic voltammetry and differential pulse voltammetry were used to explore the diffusion and linearity behaviors of OLZ. Impedance spectroscopy measurements were determined to investigate the ac behavior of OLZ and then an ideal electrical circuit was modeled. A linear calibration was obtained from 1.0 × 10-8 to 1.25 × 10-4 M. The limit of detection was 1.5 × 10-9 M, whereas the limit of quantification was 5 × 10-9 M. The way has been wholly authenticated concerning linearity, precision, accuracy, reproducibility, sensitivity, and selectivity.

SUBMITTER: Azab SM

PROVIDER: S-EPMC6648889 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Role of Green Chemistry in Antipsychotics' Electrochemical Investigations Using a Nontoxic Modified Sensor in McIlvaine Buffer Solution.

Azab Shereen M SM Fekry Amany M AM

ACS omega 20190102 1

A new low-cost green electrochemical sensor based on nontoxic polyethylene glycol (PEG) and silver nanoparticles was used to improve the sensitivity of the carbon paste electrode for the investigation of olanzapine (OLZ) in dosage arrangements and in the existence of its coadministered drug fluoxetine and in the drug formulation. Scanning electron microscopy measurements were carried out to emphasize the morphology of the electrode surface. Cyclic voltammetry and differential pulse voltammetry w ...[more]

PMID: 31459308

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Project description:Trace determination of radioactive waste, especially Ce3+, by electrochemical methods has rarely been attempted. Ce3+ is (i) a fluorescence quencher, (ii) an antiferromagnet, and (iii) a superconductor, and it has been incorporated into fast scintillators, LED phosphors, and fluorescent lamps. Although Ce3+ has been utilized in many industries due to its specific properties, it causes severe health problems to human beings because of its toxicity. Nanomaterials with fascinating electrical properties can play a vital role in the fabrication of a sensor device to detect the analyte of interest. In the present study, surfactant-free 1,8-diaminonaphthalene (DAN)-functionalized graphene quantum dots (DAN-GQDs) with nanobud (NB) morphology were utilized for the determination of Ce3+ through electrochemical studies. The working electrode, graphene nanobud (GNB)-modified-carbon felt (CF), was developed by a simple drop-coating method for the sensitive detection of Ce3+ in acetate buffer solution (ABS, pH 4.0 ± 0.05) at a scan rate of 50 mV s-1 using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. CV and DPV studies validated the existence of distinctive peaks at approximately +0.20 and +0.93 V (vs. SCE), respectively, with a limit of detection of approximately 2.60 μM. Furthermore, electrochemical studies revealed that the GNB-modified-CF electrode was (i) stable even after fifteen cycles, (ii) reproducible, (iii) selective towards Ce3+, (iv) strongly pH-dependent, and (v) favored Ce3+ sensing only at pH 4.0 ± 0.05. Impedance spectroscopy results indicated that the GNB-modified-CF electrode was more conductive (1.38 × 10-4 S m-1) and exhibited more rapid electron transfer than bare CF, which agrees with the attained Randles equivalent circuit. Microscopy (AFM, FE-SEM, and HR-TEM), spectroscopy (XPS and Raman), XRD, and energy-dispersive X-ray (EDX) analyses of the GNB-modified-CF electrode confirmed the adsorption of Ce3+ onto the electrode surface and the size of the electrode material. Ce3+ nanobuds increased from 35-40 to 50-55 nm without changing their morphology. The obtained results provide an insight into the determination of Ce3+ to develop an electrochemical device with low sensitivity.

Dataset Information

Role of Green Chemistry in Antipsychotics' Electrochemical Investigations Using a Nontoxic Modified Sensor in McIlvaine Buffer Solution.

Publications

Role of Green Chemistry in Antipsychotics' Electrochemical Investigations Using a Nontoxic Modified Sensor in McIlvaine Buffer Solution.

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