Ontology highlight
ABSTRACT:
SUBMITTER: Maslivetc VA
PROVIDER: S-EPMC6667834 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
The Journal of organic chemistry 20181030 22
A strain-release-driven, cation-templated nucleophilic 7- and 8- exo-trig-cyclization of tethered Boc-protected amines to cyclopropenes is described. The featured reaction proceeds in diastereo- and regioselective fashion and allows for preparation of the corresponding 2,5-diazabicyclo[5.1.0]octan-6-ones and 2,6-diazabicyclo[6.1.0]nonan-7-ones as sole products in high yields. Preliminary studies on anticancer activities of these novel cyclopropane-fused medium heterocycles were performed. ...[more]