Ontology highlight
ABSTRACT:
SUBMITTER: Vrahnas C
PROVIDER: S-EPMC6668467 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Vrahnas Christina C Blank Martha M Dite Toby A TA Tatarczuch Liliana L Ansari Niloufar N Crimeen-Irwin Blessing B Nguyen Huynh H Forwood Mark R MR Hu Yifang Y Ikegame Mika M Bambery Keith R KR Petibois Cyril C Mackie Eleanor J EJ Tobin Mark J MJ Smyth Gordon K GK Oakhill Jonathan S JS Martin T John TJ Sims Natalie A NA
Nature communications 20190731 1
Mineralized bone forms when collagen-containing osteoid accrues mineral crystals. This is initiated rapidly (primary mineralization), and continues slowly (secondary mineralization) until bone is remodeled. The interconnected osteocyte network within the bone matrix differentiates from bone-forming osteoblasts; although osteoblast differentiation requires EphrinB2, osteocytes retain its expression. Here we report brittle bones in mice with osteocyte-targeted EphrinB2 deletion. This is not caused ...[more]