PI3K-AKT-mTOR and NF?B Pathways in Ovarian Cancer: Implications for Targeted Therapeutics.
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ABSTRACT:
SUBMITTER: Ghoneum A
PROVIDER: S-EPMC6679095 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Publications
PI3K-AKT-mTOR and NFκB Pathways in Ovarian Cancer: Implications for Targeted Therapeutics.
Cancers 20190705 7
Ovarian cancer is the most lethal gynecologic malignancy in the United States, with an estimated 22,530 new cases and 13,980 deaths in 2019. Recent studies have indicated that the phosphoinositol 3 kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR), as well as the nuclear factor-κ light chain enhancer of activated B cells (NFκB) pathways are highly mutated and/or hyper-activated in a majority of ovarian cancer patients, and are associated with advanced grade and stage dise ...[more]
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