64Cu-Labeled Ubiquitin for PET Imaging of CXCR4 Expression in Mouse Breast Tumor.
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ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC6682141 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Publications
<sup>64</sup>Cu-Labeled Ubiquitin for PET Imaging of CXCR4 Expression in Mouse Breast Tumor.
Li Huiqiang H Zhang Xiaohui X Wu Hsuan Yi HY Sun Lingyi L Ma Yongyong Y Xu Junling J Lin Qing Q Zeng Dexing D
ACS omega 20190722 7
Ubiquitin has been recently identified as a chemokine receptor 4 (CXCR4) natural ligand, offering great potential for positron emission computed tomography (PET) imaging of CXCR4 expression. This study reports the preparation and evaluation of (<sup>64</sup>Cu)-radiolabeled ubiquitin for CXCR4 imaging. The ubiquitin was first fused with a C-terminal GGCGG sequence, and the resulting recombinant ubiquitin derivative UbCG4 was then functionalized with the <i>trans</i>-cyclooctene (TCO) moiety via ...[more]
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