PET Imaging of VEGFR with a Novel 64Cu-Labeled Peptide.
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ABSTRACT:
SUBMITTER: Hu K
PROVIDER: S-EPMC7178340 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Publications
PET Imaging of VEGFR with a Novel <sup>64</sup>Cu-Labeled Peptide.
Hu Kuan K Shang Jingjie J Xie Lin L Hanyu Masayuki M Zhang Yiding Y Yang Zhimin Z Xu Hao H Wang Lu L Zhang Ming-Rong MR
ACS omega 20200408 15
Vascular endothelial growth factor receptors (VEGFRs) are well recognized as significant biomarkers of tumor angiogenesis. Herein, we have developed a first-of-its-kind peptide-based VEGFR positron emission tomography (PET) tracer. The novel [<sup>64</sup>Cu]VEGF<sub>125-136</sub> peptide possessed satisfactory radio-characteristics and showed good specificity for the visualization of VEGFR in various mouse models, in which the tumor-specific radioactivity uptake was highly correlated to the VEG ...[more]
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