64Cu-Labeled multifunctional dendrimers for targeted tumor PET imaging.
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ABSTRACT:
SUBMITTER: Ma W
PROVIDER: S-EPMC7473786 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
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<sup>64</sup>Cu-Labeled multifunctional dendrimers for targeted tumor PET imaging.
Ma Wenhui W Fu Fanfan F Zhu Jingyi J Huang Rui R Zhu Yizhou Y Liu Zhenwei Z Wang Jing J Conti Peter S PS Shi Xiangyang X Chen Kai K
Nanoscale 20180301 13
We report the use of multifunctional folic acid (FA)-modified dendrimers as a platform to radiolabel with 64Cu for PET imaging of folate receptor (FR)-expressing tumors. In this study, amine-terminated generation 5 (G5) poly(amidoamine) dendrimers were sequentially modified with fluorescein isothiocyanate (FI), FA, and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), followed by acetylation of the remaining dendrimer terminal amines. The as-formed multifunctional DOTA-FA-FI-G5·NH ...[more]
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