Ontology highlight
ABSTRACT:
SUBMITTER: Petho L
PROVIDER: S-EPMC6720970 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Pethő Lilla L Mező Gábor G Schlosser Gitta G
Molecules (Basel, Switzerland) 20190816 16
Peptide-based small molecule drug conjugates for targeted tumor therapy are currently in the focus of intensive research. Anthracyclines, like daunomycin, are commonly used anticancer drug molecules and are also often applied in peptide-drug conjugates. However, lability of the <i>O</i>-glycosidic bond during electrospray ionization mass spectrometric analysis hinders the analytical characterization of the constructs. "Overprotonation" can occur if daunomycin is linked to positively charged pept ...[more]