Ontology highlight
ABSTRACT:
SUBMITTER: Nishimura T
PROVIDER: S-EPMC6739424 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Nishimura Taki T Gecht Michael M Covino Roberto R Hummer Gerhard G Surma Michal A MA Klose Christian C Arai Hiroyuki H Kono Nozomu N Stefan Christopher J CJ
Molecular cell 20190808 5
The plasma membrane (PM) is composed of a complex lipid mixture that forms heterogeneous membrane environments. Yet, how small-scale lipid organization controls physiological events at the PM remains largely unknown. Here, we show that ORP-related Osh lipid exchange proteins are critical for the synthesis of phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P<sub>2</sub>], a key regulator of dynamic events at the PM. In real-time assays, we find that unsaturated phosphatidylserine (PS) and sterols ...[more]