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A New Fluorescent Chemosensor for Cobalt(II) Ions in Living Cells Based on 1,8-Naphthalimide.


ABSTRACT: In this work, a highly selective fluorescent chemosensor N-(2-(2-butyl-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl)hydrazine-1-carbonothioyl)benzamide (L) was prepared and characterized. An assay to detect the presence of cobalt(II) ions was developed by utilizing turn-on fluorescence enhancement with visual colorimetric response. Upon treatment with Co2+, a remarkable fluorescence enhancement located at 450 nm was visible to naked eyes accompanied with a distinct color change (from pink to colorless) in a CH3CN/HEPES (4/1, v/v, pH = 7.4) solution due to the formation of a 1:1 complex at room temperature. In addition, the linear concentration range for Co2+ was 0-25 µM with the limit of detection down to 0.26 µM. Thus, a highly sensitive fluorescent method based on chelation-assisted fluorescence enhancement was developed for the trace-level detection of Co2+. The sensor was found to be highly selective toward Co2+ ions with a large number of coexisting ions. Furthermore, the L probe can serve as a fluorescent sensor for Co2+ detecting in biological environments, demonstrating its low toxic properties to organisms and good cell permeability in live cell imaging.

SUBMITTER: Liu YL 

PROVIDER: S-EPMC6749574 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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A New Fluorescent Chemosensor for Cobalt(II) Ions in Living Cells Based on 1,8-Naphthalimide.

Liu Yu-Long YL   Yang Liu L   Li Lu L   Guo You-Quan YQ   Pang Xiao-Xiao XX   Li Ping P   Ye Fei F   Fu Ying Y  

Molecules (Basel, Switzerland) 20190826 17


In this work, a highly selective fluorescent chemosensor <i>N</i>-(2-(2-<i>butyl</i>-1,3-dioxo-2,3-dihydro-1<i>H</i>-benzo[<i>de</i>]isoquinolin-6-yl)hydrazine-1-carbonothioyl)benzamide (<b>L</b>) was prepared and characterized. An assay to detect the presence of cobalt(II) ions was developed by utilizing turn-on fluorescence enhancement with visual colorimetric response. Upon treatment with Co<sup>2+</sup>, a remarkable fluorescence enhancement located at 450 nm was visible to naked eyes accomp  ...[more]

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