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Visible-light-mediated deuteration of silanes with deuterium oxide.

ABSTRACT: Isotopically labeled compounds are highly desirable as they can serve as both mechanistic probes in chemistry and diagnostic tools in medicinal research. Herein, we report an unprecedented visible-light-mediated metal-free deuteration of silanes using D₂O as an inexpensive, readily available, and easy to handle deuterium source. A broad range of aryl- and alkyl-substituted silanes were deuterated with high deuterium incorporations and yields. Furthermore, a 100 gram-scale synthesis was demonstrated using continuous-flow micro-tubing reactors, where enhanced reaction efficiency was obtained. The photoredox-catalyzed polarity matched hydrogen atom transfer (HAT) between silanes and the thiol HAT catalyst was responsible for the efficient deuteration.

SUBMITTER: Zhou R

PROVIDER: S-EPMC6764258 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Visible-light-mediated deuteration of silanes with deuterium oxide.

Zhou Rong R Li Jiesheng J Cheo Han Wen HW Chua Rachel R Zhan Gu G Hou Zhaomin Z Wu Jie J

Chemical science 20190708 31

Isotopically labeled compounds are highly desirable as they can serve as both mechanistic probes in chemistry and diagnostic tools in medicinal research. Herein, we report an unprecedented visible-light-mediated metal-free deuteration of silanes using D<sub>2</sub>O as an inexpensive, readily available, and easy to handle deuterium source. A broad range of aryl- and alkyl-substituted silanes were deuterated with high deuterium incorporations and yields. Furthermore, a 100 gram-scale synthesis wa ...[more]

PMID: 31588300

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