Ontology highlight
ABSTRACT:
SUBMITTER: Prud'homme M
PROVIDER: S-EPMC6834958 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Prud'homme Mathilde M Coutrot Maxime M Michel Thibault T Boutin Louis L Genest Magali M Poirier Françoise F Launay Jean-Marie JM Kane Bocar B Kinugasa Satoshi S Prakoura Niki N Vandermeersch Sophie S Cohen-Solal Alain A Delcayre Claude C Samuel Jane-Lise JL Mehta Ravindra R Gayat Etienne E Mebazaa Alexandre A Chadjichristos Christos E CE Legrand Matthieu M
JACC. Basic to translational science 20191028 6
Acute kidney injury is associated with increased risk of heart failure and mortality. This study demonstrates that acute kidney injury induces remote cardiac dysfunction, damage, injury, and fibrosis via a galectin-3 (Gal-3) dependent pathway. Gal-3 originates from bone marrow-derived immune cells. Cardiac damage could be prevented by blocking this pathway. ...[more]