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Light-induced metal-free transformations of unactivated pyridotriazoles.

ABSTRACT: A highly efficient and practical method for incorporation of the arylmethylpyridyl moiety into diverse molecules has been developed. This method features the transition metal-free light-induced room temperature transformation of pyridotriazoles into pyridyl carbenes, which are capable of smooth arylation, X-H insertion, and cyclopropanation reactions. The synthetic usefulness of the developed method was illustrated in a facile synthesis of biologically active molecules.

SUBMITTER: Zhang Z

PROVIDER: S-EPMC6844233 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Light-induced metal-free transformations of unactivated pyridotriazoles.

Zhang Ziyan Z Yadagiri Dongari D Gevorgyan Vladimir V

Chemical science 20190725 36

A highly efficient and practical method for incorporation of the arylmethylpyridyl moiety into diverse molecules has been developed. This method features the transition metal-free light-induced room temperature transformation of pyridotriazoles into pyridyl carbenes, which are capable of smooth arylation, X-H insertion, and cyclopropanation reactions. The synthetic usefulness of the developed method was illustrated in a facile synthesis of biologically active molecules. ...[more]

PMID: 31803418

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