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Sacrificial Bioprinting of a Mammary Ductal Carcinoma Model.

ABSTRACT: Cancer tissue engineering has remained challenging due to the limitations of the conventional biofabrication techniques to model the complex tumor microenvironment. Here, the utilization of a sacrificial bioprinting strategy is reported to generate the biomimetic mammary duct-like structure within a hydrogel matrix, which is further populated with breast cancer cells, to model the genesis of ductal carcinoma and its subsequent outward invasion. This bioprinted mammary ductal carcinoma model provides a proof-of-concept demonstration of the value of using the sacrificial bioprinting technique for engineering biologically relevant cancer models, which may be possibly extended to other cancer types where duct-like structures are involved.

SUBMITTER: Duchamp M

PROVIDER: S-EPMC6844259 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Sacrificial Bioprinting of a Mammary Ductal Carcinoma Model.

Duchamp Margaux M Liu Tingting T van Genderen Anne M AM Kappings Vanessa V Oklu Rahmi R Ellisen Leif W LW Zhang Yu Shrike YS

Biotechnology journal 20190527 10

Cancer tissue engineering has remained challenging due to the limitations of the conventional biofabrication techniques to model the complex tumor microenvironment. Here, the utilization of a sacrificial bioprinting strategy is reported to generate the biomimetic mammary duct-like structure within a hydrogel matrix, which is further populated with breast cancer cells, to model the genesis of ductal carcinoma and its subsequent outward invasion. This bioprinted mammary ductal carcinoma model prov ...[more]

PMID: 30963705

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