The role of receptor MAS in microglia-driven retinal vascular development.
Ontology highlight
ABSTRACT: Objective
The receptor MAS, encoded by Mas1, is expressed in microglia and its activation has been linked to anti-inflammatory actions. However, microglia are involved in several different processes in the central nervous system, including the promotion of angiogenesis. We therefore hypothesized that the receptor MAS also plays a role in angiogenesis via microglia.Approach and results
To assess the role of MAS on vascular network development, flat-mounted retinas from 3-day-old wild-type (WT) and Mas1-/- mice were subjected to Isolectin B4 staining. The progression of the vascular front was reduced (- 24%, p?-/- compared to WT mice with no change in the junction density. The number of filopodia and filopodia bursts were decreased in Mas1-/- mice at the vascular front (- 21%, p -/- mice (-32%, p?ConclusionsOur study demonstrates that the activation of MAS is important for microglia recruitment and vascular growth in the developing retina.
SUBMITTER: Foulquier S
PROVIDER: S-EPMC6863789 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Publications
The role of receptor MAS in microglia-driven retinal vascular development.
Foulquier S S Caolo V V Swennen G G Milanova I I Reinhold S S Recarti C C Alenina N N Bader M M Steckelings U M UM Vanmierlo T T Post M J MJ Jones E A EA van Oostenbrugge R J RJ Unger T T
Angiogenesis 20190620 4
<h4>Objective</h4>The receptor MAS, encoded by Mas1, is expressed in microglia and its activation has been linked to anti-inflammatory actions. However, microglia are involved in several different processes in the central nervous system, including the promotion of angiogenesis. We therefore hypothesized that the receptor MAS also plays a role in angiogenesis via microglia.<h4>Approach and results</h4>To assess the role of MAS on vascular network development, flat-mounted retinas from 3-day-old w ...[more]
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