Ontology highlight
ABSTRACT:
SUBMITTER: Bonnemaijer PWM
PROVIDER: S-EPMC6881308 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Bonnemaijer Pieter W M PWM Leeuwen Elisabeth M van EMV Iglesias Adriana I AI Gharahkhani Puya P Vitart Veronique V Khawaja Anthony P AP Simcoe Mark M Höhn René R Cree Angela J AJ Igo Rob P RP Gerhold-Ay Aslihan A Nickels Stefan S Wilson James F JF Hayward Caroline C Boutin Thibaud S TS Polašek Ozren O Aung Tin T Khor Chiea Chuen CC Amin Najaf N Lotery Andrew J AJ Wiggs Janey L JL Cheng Ching-Yu CY Hysi Pirro G PG Hammond Christopher J CJ Thiadens Alberta A H J AAHJ MacGregor Stuart S Klaver Caroline C W CCW Duijn Cornelia M van CMV
Communications biology 20191127
A new avenue of mining published genome-wide association studies includes the joint analysis of related traits. The power of this approach depends on the genetic correlation of traits, which reflects the number of pleiotropic loci, i.e. genetic loci influencing multiple traits. Here, we applied new meta-analyses of optic nerve head (ONH) related traits implicated in primary open-angle glaucoma (POAG); intraocular pressure and central corneal thickness using Haplotype reference consortium imputat ...[more]