Ontology highlight
ABSTRACT:
SUBMITTER: De Jesus DF
PROVIDER: S-EPMC6924515 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
De Jesus Dario F DF Zhang Zijie Z Kahraman Sevim S Brown Natalie K NK Chen Mengjie M Hu Jiang J Gupta Manoj K MK He Chuan C Kulkarni Rohit N RN
Nature metabolism 20190729 8
The regulation of islet cell biology is critical for glucose homeostasis<sup>1</sup>.<i>N<sup>6</sup></i> -methyladenosine (m<sup>6</sup>A) is the most abundant internal messenger RNA (mRNA) modification in mammals<sup>2</sup>. Here we report that the m<sup>6</sup>A landscape segregates human type 2 diabetes (T2D) islets from controls significantly better than the transcriptome and that m<sup>6</sup>A is vital for β-cell biology. m<sup>6</sup>A-sequencing in human T2D islets reveals several hypo ...[more]