Ontology highlight
ABSTRACT:
SUBMITTER: Jang MA
PROVIDER: S-EPMC6960053 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
The Korean journal of internal medicine 20191129 1
Myeloproliferative neoplasms (MPNs) are a heterogeneous group of clonal disorders characterized by the overproduction of mature blood cells that have an increased risk of thrombosis and progression to acute myeloid leukemia. Next-generation sequencing studies have provided key insights regarding the molecular mechanisms of MPNs. MPN driver mutations in genes associated with the JAK-STAT pathway include JAK2 V617F, JAK2 exon 12 mutations and mutations in MPL, CALR, and CSF3R. Cooperating driver g ...[more]