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Author's View: a nuclear transcription factor relocalizing to mitochondria rescues cells from proteotoxic aggregates.

ABSTRACT: Mitochondrial proteostasis is essential for survival, and imbalances can result in severe human diseases. We identified a novel stress response triggered upon accumulation of proteotoxic aggregates in the mitochondrial matrix. Mitochondria-to-nucleus signaling results in a transcriptional response and translocation of a nuclear transcription factor into mitochondria to maintain mitochondrial gene expression.

SUBMITTER: Taskin AA

PROVIDER: S-EPMC6961659 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Author's View: a nuclear transcription factor relocalizing to mitochondria rescues cells from proteotoxic aggregates.

Taskin Asli Aras AA Poveda-Huertes Daniel D Vögtle F-Nora FN

Molecular & cellular oncology 20191210 1

Mitochondrial proteostasis is essential for survival, and imbalances can result in severe human diseases. We identified a novel stress response triggered upon accumulation of proteotoxic aggregates in the mitochondrial matrix. Mitochondria-to-nucleus signaling results in a transcriptional response and translocation of a nuclear transcription factor into mitochondria to maintain mitochondrial gene expression. ...[more]

PMID: 31993502

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