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GSTP1 exon 5 rs200139798 polymorphism and clinicopathological characteristics of gastric cancer in Chinese patients.

ABSTRACT: This study was undertaken to detect the incidence of variations in exon 5 of GSTP1, a member of the glutathione-S-transferase family, in gastric cancer in relation to histological parameters. The study included 216 gastric cancers and 300 benign gastric diseases as controls. DNA was extracted from paraffin-embedded tissues and polymerase chain reaction-restriction fragment length polymorphism analysis was performed to examine the GSTP1 Ile105Val gene polymorphism in the study participants. A positive association between GSTP1 polymorphism and gastric cancer was observed in subjects carrying at least one G allele (AG and GG); the adjusted odds ratio (OR) for GSTP1 AA versus AG+GG was 1.416 (95% confidence interval [CI] 1.007 to 1.989, after controlling for age and gender). Patients over 50 years old more frequently carried the AG+GG genotype than those aged less than 50 (P=0.011) with adjusted OR (95% CI) of 2.758 (1.227-6.201). Compared with the well-differentiated group, the incidence of the GSTP1 AA genotype was decreased in the moderately [P=0.026; OR (95% CI)=3.559 (1.072-11.813)] and poorly [P=0.003; OR (95% CI)=6.015 (1.679-21.549)] differentiated groups. The incidence of the GSTP1 AA genotype in intestinal type was higher than that in diffuse type (adjusted P=0.014; OR [95% CI]=2.210 [1.160-4.210]). All results indicated that the GSTP1 Ile105Val variant was closely associated with an increased risk of gastric cancer, and was significantly associated with patient age, tissue differentiation degree, and Lauren classification but not with gender, gross classification, tumor size (diameter), infiltration depth, and lymph node involvement.

SUBMITTER: Wang X

PROVIDER: S-EPMC6965944 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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GSTP1 exon 5 rs200139798 polymorphism and clinicopathological characteristics of gastric cancer in Chinese patients.

Wang Xuguang X Zhang Zhong Z Liang Li L Bo Wei W Zhang Min M Wang Yanning Y Pan Xiaowei X

International journal of clinical and experimental pathology 20170901 9

This study was undertaken to detect the incidence of variations in exon 5 of <i>GSTP1</i>, a member of the glutathione-S-transferase family, in gastric cancer in relation to histological parameters. The study included 216 gastric cancers and 300 benign gastric diseases as controls. DNA was extracted from paraffin-embedded tissues and polymerase chain reaction-restriction fragment length polymorphism analysis was performed to examine the GSTP1 Ile105Val gene polymorphism in the study participants ...[more]

PMID: 31966884

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Project description:Background and Objectives: One of the most frequent genetic alterations reported to date in prostate cancer (PC) is aberrant methylation of glutathione transferase P1 (GSTP1). Taking into consideration the involvement of oxidative stress in PC pathogenesis and recent advances in scientific understanding of the role of GSTP1*Ala114Val rs1138272 polymorphism in carcinogenesis, we hypothesized that this single-nucleotide polymorphism (SNP) influences the risk of PC independently of, or in combination with, other GST polymorphisms, including GSTP1*IIe105Val rs1695 or GSTM1 and GSTT1 deletion polymorphisms. Materials and Methods: Genotyping was performed in 237 PC cases and in 236 age-matched controls by multiplex polymerase chain reaction (PCR) for deletion of GST polymorphisms and by quantitative PCR for SNPs. Results: We found that carriers of either GSTP1*Val (rs1138272) or GSTP1*Val (rs1695) variant alleles had a PC risk compared to individuals with both referent alleles (OR = 4.93, 95%CI: 2.89-8.40, p < 0.001 and OR = 1.8, 95%CI: 1.19-2.73, p = 0.006, respectively). Additionally, in a haplotype analysis we found that individuals with GSTP1*C haplotype, represented by both variant alleles (GSTP1*Val rs1695 + GSTP1*Val rs1138272), had a 5.46 times higher risk of PC development compared to individuals with the most frequent haplotype (95%CI = 2.56-11.65, p < 0.001), suggesting a potential role of those variants in PC susceptibility. A regression analysis on the number of risk-associated alleles per individual (GSTM1*active, GSTT1*null, GSTP1*Val rs1695 and GSTP1*Val rs1138272) showed a significant increase in the risk of developing PC, from 3.65-fold in carriers of two risk alleles (95%CI = 1.55-8.61, p = 0.003) to an approximately 12-fold increase in carriers of all four risk alleles (95%CI = 3.05-44.93, p < 0.001). Conclusion: Prostate cancer may be influenced by multiple glutathione transferase (GST) polymorphic genes, especially GSTP1, highlighting the role of gene-gene interactions in human susceptibility to this cancer.

Dataset Information

GSTP1 exon 5 rs200139798 polymorphism and clinicopathological characteristics of gastric cancer in Chinese patients.

Publications

GSTP1 exon 5 rs200139798 polymorphism and clinicopathological characteristics of gastric cancer in Chinese patients.

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