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Anthranilamide-based Short Peptides Self-Assembled Hydrogels as Antibacterial Agents.

ABSTRACT: In this study, we describe the synthesis and molecular properties of anthranilamide-based short peptides which were synthesised via ring opening of isatoic anhydride in excellent yields. These short peptides were incorporated as low molecular weight gelators (LMWG), bola amphiphile, and C₃-symmetric molecules to form hydrogels in low concentrations (0.07-0.30% (w/v)). The critical gel concentration (CGC), viscoelastic properties, secondary structure, and fibre morphology of these short peptides were influenced by the aromaticity of the capping group or by the presence of electronegative substituent (namely fluoro) and hydrophobic substituent (such as methyl) in the short peptides. In addition, the hydrogels showed antibacterial activity against S. aureus 38 and moderate toxicity against HEK cells in vitro.

SUBMITTER: Aldilla VR

PROVIDER: S-EPMC6972728 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Anthranilamide-based Short Peptides Self-Assembled Hydrogels as Antibacterial Agents.

Aldilla Vina R VR Chen Renxun R Martin Adam D AD Marjo Christopher E CE Rich Anne M AM Black David StC DS Thordarson Pall P Kumar Naresh N

Scientific reports 20200121 1

In this study, we describe the synthesis and molecular properties of anthranilamide-based short peptides which were synthesised via ring opening of isatoic anhydride in excellent yields. These short peptides were incorporated as low molecular weight gelators (LMWG), bola amphiphile, and C<sub>3</sub>-symmetric molecules to form hydrogels in low concentrations (0.07-0.30% (w/v)). The critical gel concentration (CGC), viscoelastic properties, secondary structure, and fibre morphology of these shor ...[more]

PMID: 31964927

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