Ontology highlight
ABSTRACT:
SUBMITTER: Waldman BS
PROVIDER: S-EPMC6978799 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Waldman Benjamin S BS Schwarz Dominic D Wadsworth Marc H MH Saeij Jeroen P JP Shalek Alex K AK Lourido Sebastian S
Cell 20200116 2
Toxoplasma gondii chronically infects a quarter of the world's population, and its recrudescence can cause life-threatening disease in immunocompromised individuals and recurrent ocular lesions in the immunocompetent. Acute-stage tachyzoites differentiate into chronic-stage bradyzoites, which form intracellular cysts resistant to immune clearance and existing therapies. The molecular basis of this differentiation is unknown, despite being efficiently triggered by stresses in culture. Through Cas ...[more]