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Enantioselective carbene insertion into the N-H bond of benzophenone imine.

ABSTRACT: Efficient enantioselective insertion of ?-diazoesters into the N-H bond of N-sp2-hybridized benzophenone imine was realized by using Rh2(esp)2 and chiral guanidine cooperative catalysis. Both aliphatic and aromatic substituted ?-amino esters were obtained in high yields (up to 99%) and good enantioselectivities (up to 95.5?:?4.5 er) under mild reaction conditions.

SUBMITTER: Yang J

PROVIDER: S-EPMC6979361 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Enantioselective carbene insertion into the N-H bond of benzophenone imine.

Yang Jian J Ruan Peiran P Yang Wei W Feng Xiaoming X Liu Xiaohua X

Chemical science 20190918 44

Efficient enantioselective insertion of α-diazoesters into the N-H bond of N-sp2-hybridized benzophenone imine was realized by using Rh2(esp)2 and chiral guanidine cooperative catalysis. Both aliphatic and aromatic substituted α-amino esters were obtained in high yields (up to 99%) and good enantioselectivities (up to 95.5 : 4.5 er) under mild reaction conditions. ...[more]

PMID: 32110317

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