Ontology highlight
ABSTRACT:
SUBMITTER: Poweleit N
PROVIDER: S-EPMC6986878 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Poweleit Nicole N Czudnochowski Nadine N Nakagawa Rachel R Trinidad Donovan D DD Murphy Kenan C KC Sassetti Christopher M CM Rosenberg Oren S OS
eLife 20191230
The ESX (or Type VII) secretion systems are protein export systems in mycobacteria and many Gram-positive bacteria that mediate a broad range of functions including virulence, conjugation, and metabolic regulation. These systems translocate folded dimers of WXG100-superfamily protein substrates across the cytoplasmic membrane. We report the cryo-electron microscopy structure of an ESX-3 system, purified using an epitope tag inserted with recombineering into the chromosome of the model organism < ...[more]