Ontology highlight
ABSTRACT:
SUBMITTER: Akkaya M
PROVIDER: S-EPMC7002124 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Akkaya Munir M Bansal Abhisheka A Sheehan Patrick W PW Pena Mirna M Molina-Cruz Alvaro A Orchard Lindsey M LM Cimperman Clare K CK Qi Chen-Feng CF Ross Philipp P Yazew Takele T Sturdevant Daniel D Anzick Sarah L SL Thiruvengadam Girija G Otto Thomas Dan TD Billker Oliver O Llinás Manuel M Miller Louis H LH Pierce Susan K SK
Science advances 20200205 6
The acquisition of malaria immunity is both remarkably slow and unpredictable. At present, we know little about the malaria parasite genes that influence the host's ability to mount a protective immune response. Here, we show that a single-nucleotide polymorphism (SNP) resulting in a single amino acid change (S to F) in an ApiAP2 transcription factor in the rodent malaria parasite <i>Plasmodium berghei</i> (<i>Pb</i>) NK65 allowed infected mice to mount a T helper cell 1 (T<sub>H</sub>1)-type im ...[more]