Ontology highlight
ABSTRACT:
SUBMITTER: Lin Q
PROVIDER: S-EPMC7003203 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Lin Qingqing Q Hopper Denham D Zhang Haoyue H Sfyris Qoon Jordan J Shen Zihan Z Karas John A JA Hughes Richard A RA Northfield Susan E SE
ACS omega 20200117 4
The chemical synthesis of cyclic peptides is a well-established area of research. This has been further expanded by development of bio-orthogonal reactions that enable access to peptides of greater structural complexity. One approach utilizes 1,3-dichloroacetone to selectively link free cysteine side-chains with an acetone-like bridge via an S<sub>N</sub>2 reaction. Here, we have used this reaction to dimerize cyclic peptide monomers to create novel bicyclic dimeric peptides. We investigated a r ...[more]