Ontology highlight
ABSTRACT:
SUBMITTER: Gronroos T
PROVIDER: S-EPMC7005266 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Grönroos Toni T Mäkinen Artturi A Laukkanen Saara S Mehtonen Juha J Nikkilä Atte A Oksa Laura L Rounioja Samuli S Marincevic-Zuniga Yanara Y Nordlund Jessica J Pohjolainen Virva V Paavonen Timo T Heinäniemi Merja M Lohi Olli O
Scientific reports 20200206 1
Acute lymphoblastic leukemia is marked by aberrant transcriptional features that alter cell differentiation, self-renewal, and proliferative features. We sought to identify the transcription factors exhibiting altered and subtype-specific expression patterns in B-ALL and report here that SOX11, a developmental and neuronal transcription factor, is aberrantly expressed in the ETV6-RUNX1 and TCF3-PBX1 subtypes of acute B-cell leukemias. We show that a high expression of SOX11 leads to alterations ...[more]