Unknown

Dataset Information

0

Clinicopathological features and prognostic value of SOX11 in childhood acute lymphoblastic leukemia.


ABSTRACT: Acute lymphoblastic leukemia is marked by aberrant transcriptional features that alter cell differentiation, self-renewal, and proliferative features. We sought to identify the transcription factors exhibiting altered and subtype-specific expression patterns in B-ALL and report here that SOX11, a developmental and neuronal transcription factor, is aberrantly expressed in the ETV6-RUNX1 and TCF3-PBX1 subtypes of acute B-cell leukemias. We show that a high expression of SOX11 leads to alterations of gene expression that are typically associated with cell adhesion, migration, and differentiation. A high expression is associated with DNA hypomethylation at the SOX11 locus and a favorable outcome. The results indicate that SOX11 expression marks a group of patients with good outcomes and thereby prompts further study of its use as a biomarker.

SUBMITTER: Gronroos T 

PROVIDER: S-EPMC7005266 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

altmetric image

Publications


Acute lymphoblastic leukemia is marked by aberrant transcriptional features that alter cell differentiation, self-renewal, and proliferative features. We sought to identify the transcription factors exhibiting altered and subtype-specific expression patterns in B-ALL and report here that SOX11, a developmental and neuronal transcription factor, is aberrantly expressed in the ETV6-RUNX1 and TCF3-PBX1 subtypes of acute B-cell leukemias. We show that a high expression of SOX11 leads to alterations  ...[more]

Similar Datasets

2018-12-18 | GSE123943 | GEO
| PRJNA510364 | ENA
2019-02-25 | PXD010175 | Pride
| S-EPMC2814411 | biostudies-literature
| S-EPMC7511595 | biostudies-literature
| S-EPMC6652134 | biostudies-literature
| S-EPMC3848419 | biostudies-literature
| S-EPMC4567699 | biostudies-literature
2020-01-29 | MSV000084862 | MassIVE
| S-EPMC3675104 | biostudies-literature