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One-Pot Conversion of Allylic Alcohols to ?-Methyl Ketones via Iron-Catalyzed Isomerization-Methylation.

ABSTRACT: A one-pot iron-catalyzed conversion of allylic alcohols to ?-methyl ketones has been developed. This isomerization-methylation strategy utilized a (cyclopentadienone)iron(0) carbonyl complex as precatalyst and methanol as the C1 source. A diverse range of allylic alcohols undergoes isomerization-methylation to form ?-methyl ketones in good isolated yields (up to 84% isolated yield).

SUBMITTER: Latham DE

PROVIDER: S-EPMC7007281 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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One-Pot Conversion of Allylic Alcohols to α-Methyl Ketones via Iron-Catalyzed Isomerization-Methylation.

Latham Daniel E DE Polidano Kurt K Williams Jonathan M J JMJ Morrill Louis C LC

Organic letters 20190919 19

A one-pot iron-catalyzed conversion of allylic alcohols to α-methyl ketones has been developed. This isomerization-methylation strategy utilized a (cyclopentadienone)iron(0) carbonyl complex as precatalyst and methanol as the C1 source. A diverse range of allylic alcohols undergoes isomerization-methylation to form α-methyl ketones in good isolated yields (up to 84% isolated yield). ...[more]

PMID: 31536370

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