Ontology highlight
ABSTRACT:
SUBMITTER: Abt ER
PROVIDER: S-EPMC7035983 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Abt Evan R ER Rosser Ethan W EW Durst Matthew A MA Lok Vincent V Poddar Soumya S Le Thuc M TM Cho Arthur A Kim Woosuk W Wei Liu L Song Janet J Capri Joseph R JR Xu Shili S Wu Nanping N Slavik Roger R Jung Michael E ME Damoiseaux Robert R Czernin Johannes J Donahue Timothy R TR Lavie Arnon A Radu Caius G CG
Cell chemical biology 20191113 2
Biosynthesis of the pyrimidine nucleotide uridine monophosphate (UMP) is essential for cell proliferation and is achieved by the activity of convergent de novo and salvage metabolic pathways. Here we report the development and application of a cell-based metabolic modifier screening platform that leverages the redundancy in pyrimidine metabolism for the discovery of selective UMP biosynthesis modulators. In evaluating a library of protein kinase inhibitors, we identified multiple compounds that ...[more]