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Distinct Subpopulations of Intravalvular Methicillin-Resistant Staphylococcus aureus with Variable Susceptibility to Daptomycin in Tricuspid Valve Endocarditis.


ABSTRACT: We present a case of endocarditis wherein organisms cultured from different valve leaflets yielded different daptomycin susceptibilities from each other and from organisms obtained from peripheral blood culture. Genomic analyses showed mutations in mprF, purR, and agrA Pharmacokinetic simulations showed consistent activity of daptomycin plus beta-lactam against all subpopulations. This represents an opportunity to understand S. aureus evolution and fitness in vivo on daptomycin therapy and the role of beta-lactams to prevent the selection of daptomycin-resistant subpopulations.

SUBMITTER: Miller CR 

PROVIDER: S-EPMC7038235 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Distinct Subpopulations of Intravalvular Methicillin-Resistant Staphylococcus aureus with Variable Susceptibility to Daptomycin in Tricuspid Valve Endocarditis.

Miller Christopher R CR   Dey Somrita S   Smolenski Paula D PD   Kulkarni Pushkar S PS   Monk Jonathan M JM   Szubin Richard R   Sakoulas George G   Berti Andrew D AD  

Antimicrobial agents and chemotherapy 20200221 3


We present a case of endocarditis wherein organisms cultured from different valve leaflets yielded different daptomycin susceptibilities from each other and from organisms obtained from peripheral blood culture. Genomic analyses showed mutations in <i>mprF, purR</i>, and <i>agrA</i> Pharmacokinetic simulations showed consistent activity of daptomycin plus beta-lactam against all subpopulations. This represents an opportunity to understand <i>S. aureus</i> evolution and fitness <i>in vivo</i> on  ...[more]

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