Ontology highlight
ABSTRACT:
SUBMITTER: Forte N
PROVIDER: S-EPMC7066670 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Forte Nafsika N Benni Irene I Karu Kersti K Chudasama Vijay V Baker James R JR
Chemical science 20191011 47
The modification of lysine residues with acylating agents has represented a ubiquitous approach to the construction of antibody conjugates, with the resulting amide bonds being robustly stable and clinically validated. However, the conjugates are highly heterogeneous, due to the presence of numerous lysines on the surface of the protein, and greater control of the sites of conjugation are keenly sought. Here we present a novel approach to achieve the targeted modification of lysines distal to an ...[more]