Ontology highlight
ABSTRACT:
SUBMITTER: Safar P
PROVIDER: S-EPMC7111795 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Tetrahedron 20160421 23
The stereoselective synthesis of <i>epi</i>-thieno analogues of the phenanthroquinolizidine bioactive alkaloids (-)-Cryptopleurine and (-)-(15<i>R</i>)-Hydroxycryptopleurine was achieved in five steps starting from easily available enantiopure (<i>S</i>)-2-aminoadipic acid used as chiral pool and nitrogen atom source. During these investigations, both π-cationic cyclization of chiral <i>N</i>-thienylmethyl-6-oxopipecolinic acids into pure (<i>S</i>)-keto-lactams and theirs regioselective and dia ...[more]