Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration.
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ABSTRACT:
SUBMITTER: Revez JA
PROVIDER: S-EPMC7118120 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
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Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration.
Revez Joana A JA Lin Tian T Qiao Zhen Z Xue Angli A Holtz Yan Y Zhu Zhihong Z Zeng Jian J Wang Huanwei H Sidorenko Julia J Kemper Kathryn E KE Vinkhuyzen Anna A E AAE Frater Julanne J Eyles Darryl D Burne Thomas H J THJ Mitchell Brittany B Martin Nicholas G NG Zhu Gu G Visscher Peter M PM Yang Jian J Wray Naomi R NR McGrath John J JJ
Nature communications 20200402 1
Vitamin D deficiency is a candidate risk factor for a range of adverse health outcomes. In a genome-wide association study of 25 hydroxyvitamin D (25OHD) concentration in 417,580 Europeans we identify 143 independent loci in 112 1-Mb regions, providing insights into the physiology of vitamin D and implicating genes involved in lipid and lipoprotein metabolism, dermal tissue properties, and the sulphonation and glucuronidation of 25OHD. Mendelian randomization models find no robust evidence that ...[more]
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