Ontology highlight
ABSTRACT:
SUBMITTER: Mourgues S
PROVIDER: S-EPMC3816466 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Mourgues Sophie S Gautier Violette V Lagarou Anna A Bordier Christine C Mourcet Amandine A Slingerland Joris J Kaddoum Lara L Coin Frédéric F Vermeulen Wim W Gonzales de Peredo Anne A Monsarrat Bernard B Mari Pierre-Olivier PO Giglia-Mari Giuseppina G
Proceedings of the National Academy of Sciences of the United States of America 20131014 44
DNA lesions that block transcription may cause cell death even when repaired, if transcription does not restart to reestablish cellular metabolism. However, transcription resumption after individual DNA-lesion repair remains poorly described in mechanistic terms and its players are largely unknown. The general transcription factor II H (TFIIH) is a major actor of both nucleotide excision repair subpathways of which transcription-coupled repair highlights the interplay between DNA repair and tran ...[more]