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ABSTRACT:
SUBMITTER: Derudas M
PROVIDER: S-EPMC7125978 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Derudas Marco M Brancale Andrea A Naesens Lieve L Neyts Johan J Balzarini Jan J McGuigan Christopher C
Bioorganic & medicinal chemistry 20100215 7
Ribavirin is a nucleoside analogue with broad antiviral activity. Here we report the synthesis and biological evaluation of novel ribavirin ProTides designed to deliver the bioactive ribavirin monophosphate into cells. Some of the compounds display activity similar to the parent nucleoside against a range of viruses. Enzymatic, cell lysate and preliminary modeling studies have been performed to investigate the lack of enhancement of potency by the ProTides, and these indicate a failure at the fi ...[more]