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Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4).

ABSTRACT: Chemokine-like factor 1 (CKLF1) exhibits chemotactic effects on leukocytes. Its amino acid sequence shares similarity with those of TARC/CCL17 and MDC/CCL22, the cognate ligands for CCR4. The chemotactic effects of CKLF1 for CCR4-transfected cells could be desensitized by TARC/CCL17 and markedly inhibited by PTX. CKLF1 induced a calcium flux in CCR4-transfected cells and fully desensitized a subsequent response to TARC/CCL17, and TARC/CCL17 could partly desensitize the response to CKLF1. CKLF1 caused significant receptor internalization in pCCR4-EGFP transfected cells. Taken together, CKLF1 is a novel functional ligand for CCR4.

SUBMITTER: Wang Y

PROVIDER: S-EPMC7126766 | biostudies-literature | 2006 Jan

REPOSITORIES: biostudies-literature

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Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4).

Wang Ying Y Zhang Yingmei Y Yang Xue X Han Wenling W Liu Yanan Y Xu Qianmei Q Zhao Rui R Di Chunhui C Song Quansheng Q Ma Dalong D

Life sciences 20050830 6

Chemokine-like factor 1 (CKLF1) exhibits chemotactic effects on leukocytes. Its amino acid sequence shares similarity with those of TARC/CCL17 and MDC/CCL22, the cognate ligands for CCR4. The chemotactic effects of CKLF1 for CCR4-transfected cells could be desensitized by TARC/CCL17 and markedly inhibited by PTX. CKLF1 induced a calcium flux in CCR4-transfected cells and fully desensitized a subsequent response to TARC/CCL17, and TARC/CCL17 could partly desensitize the response to CKLF1. CKLF1 c ...[more]

PMID: 16137713

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