Ontology highlight
ABSTRACT:
SUBMITTER: Facciotti F
PROVIDER: S-EPMC7132288 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Facciotti F F Larghi P P Bosotti R R Vasco C C Gagliani N N Cordiglieri C C Mazzara S S Ranzani V V Rottoli E E Curti S S Penatti A A Karnani B B Kobayashi Y Y Crosti M M Bombaci M M van Hamburg J P JP Rossetti G G Gualtierotti R R Gerosa M M Gatti S S Torretta S S Pignataro L L Tas S W SW Abrignani S S Pagani M M Grassi F F Meroni P L PL Flavell R A RA Geginat J J
Proceedings of the National Academy of Sciences of the United States of America 20200317 13
Interleukin 10 (IL-10) is an antiinflammatory cytokine, but also promotes B cell responses and plays a pathogenic role in systemic lupus erythematosus (SLE). CD4<sup>+</sup>CCR6<sup>+</sup>IL-7R<sup>+</sup>T cells from human tonsils produced IL-10 following stimulation by naïve B cells, which promoted B cell immunoglobulin G (IgG) production. These tonsillar CCR6<sup>+</sup>B helper T cells were phenotypically distinct from follicular helper T (T<sub>FH</sub>) cells and lacked BCL6 expression. I ...[more]