Ontology highlight
ABSTRACT:
SUBMITTER: Odegard JM
PROVIDER: S-EPMC2585848 | biostudies-other | 2008 Nov
REPOSITORIES: biostudies-other
Odegard Jared M JM Marks Benjamin R BR DiPlacido Leah D LD Poholek Amanda C AC Kono Dwight H DH Dong Chen C Flavell Richard A RA Craft Joe J
The Journal of experimental medicine 20081103 12
The role of specialized follicular helper T (T(FH)) cells in the germinal center has become well recognized, but it is less clear how effector T cells govern the extrafollicular response, the dominant pathway of high-affinity, isotype-switched autoantibody production in the MRL/MpJ-Fas(lpr) (MRL(lpr)) mouse model of lupus. MRL(lpr) mice lacking the Icos gene have impaired extrafollicular differentiation of immunoglobulin (Ig) G(+) plasma cells accompanied by defects in CXC chemokine receptor (CX ...[more]