Ontology highlight
ABSTRACT:
SUBMITTER: Cervera-Carrascon V
PROVIDER: S-EPMC7163046 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Cervera-Carrascon Victor V Quixabeira Dafne C A DCA Havunen Riikka R Santos Joao M JM Kutvonen Emma E Clubb James H A JHA Siurala Mikko M Heiniö Camilla C Zafar Sadia S Koivula Teija T Lumen Dave D Vaha Marjo M Garcia-Horsman Arturo A Airaksinen Anu J AJ Sorsa Suvi S Anttila Marjukka M Hukkanen Veijo V Kanerva Anna A Hemminki Akseli A
Molecular therapy oncolytics 20200319
Despite some promising results, the majority of patients do not benefit from T cell therapies, as tumors prevent T cells from entering the tumor, shut down their activity, or downregulate key antigens. Due to their nature and mechanism of action, oncolytic viruses have features that can help overcome many of the barriers currently facing T cell therapies of solid tumors. This study aims to understand how four different oncolytic viruses (adenovirus, vaccinia virus, herpes simplex virus, and reov ...[more]