Ontology highlight
ABSTRACT:
SUBMITTER: Liu F
PROVIDER: S-EPMC7184887 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Liu Fangyu F Zhang Zhe Z Levit Anat A Levring Jesper J Touhara Kouki K KK Shoichet Brian K BK Chen Jue J
Science (New York, N.Y.) 20190601 6446
Cystic fibrosis is a fatal disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR). Two main categories of drugs are being developed: correctors that improve folding of CFTR and potentiators that recover the function of CFTR. Here, we report two cryo-electron microscopy structures of human CFTR in complex with potentiators: one with the U.S. Food and Drug Administration (FDA)-approved drug ivacaftor at 3.3-angstrom resolution and the other with an investigat ...[more]